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We are aware of the fact that you may encounter this issue after updating your game to 1.10 using GOG Galaxy.

If new version of the game does not want to load your save games, saying they are not compatible and GOG Galaxy says that you are up to date and the Free DLC program is installed - you may want to try the following workaround:

1. Start the GOG Galaxy, and log in;
2. Select The Witcher 3 in the game list, and go to its configuration pane (MORE -> CONFIGURE);
3. Untick the Free DLC program checkbox (if it's checked);
4. Wait for the application to finish the uninstallation process;
5. Tick the Free DLC program checkbox;
6. Wait for the application to install the DLC;
The Free DLC program should now be installed and The Witcher 3 should be able to load your saved games.

We will fix this problem as soon as possible. Sorry for the inconvenience you may have encountered.
Post edited October 10, 2015 by songoqu
Random crashes upon starting the game
delete the d3d11 and dxgi dlls from bin/x64 in game folder.
Harry85217: After the 1.10 update (PC) i get the Error 0xc000007b when staring the game. Previously with patch 1.084 there are no problems.
did you try to remove files listed above?