Hi guys, I just wanted to share some good news that made my playing of the Witcher 2 possible. I have had countless of crashing to desktop and I almost gave up on fixing it, for some reason these crashes came specially when an autosave or a quicksave was done. To make things short, it was driving me nuts for weeks.

Found the fix, I lowered down the texture memory size to medium. It seemed that at least in my case, my computer would try to load textures way faster than it should and it would crash, I can't explain it correctly but that was the case here, I am 100% sure of it.

Before I forget, I play everything on ultra except ubersampling, texture memory size medium and LOD normal.

My rig is:
Athlon II x2 250 3.75ghz
Radeon HD 6950 1gb
Windows 7 32 bit.

Cheers, and I hope someone tries this fix, believe me it works and it doesn't lower the texture quality only the loading of it.

Your processor looks disproportionally worse than your GPU. Your fix looks right for you but maybe not everyone. I'm sure it will be helpful to some others regardless.

I play Crysis 2 on extreme settings at 60 fps only because I have vsync on so I don't think my CPU is having much problems with the GPU, it could be better though I guess.

And yes, I too hope is helpful to some others regardless.

I discovered another solution:

This game makes an absurd amount of autosaves, and every one of those saves takes a few megs on your hard drive. I noticed that the crashes started to happen when the number of saves on file reaches a prodigious amount.

You can fix the problem, therefore, by cleaning up the saves directory every so often. Delete all of your autosaves, or all but the most recent, or move the saves you can't bear to destroy to another folder. I deleted about 120 files from my saves directory, and the crashing stopped.