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untamed: Frozr 580 GTX OC, I7 2600k, 8GB RAM, 120GB SSD

I can play fine on High settings but only get about 15fps on Ultra, so I'm guessing you'll need multiple cards in SLI/Crossfire to be able to play properly in Ultra.

(Latest nvidia drivers including 3d btw)

Edit:
After some tweaking (basically just turning off ubersampling in advanced menu) I'm able to play on ultra settings
Yes me too , the game is stunning everything maxed and runs like a charm! i believe somehow uses both cores from the 5970, The Witcher 2 graphics are insane it seems all the time like a movie or better i can't believe it! i am very very happy :)
Using this configuration (old I know) on ULTRA (UberSample OFF) :

E8500 (not OCed)
4Gb ram (800 MHz)
XFX GTX 260+ (latest stable driver, no 3D)
Win7 Pro 32b


Works quite well, still have to try the outdoors scene but seems to work like a charm...