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I used all the recommended mods from The game looked and played great. I can't say that it's preferable to unmodded for a first play, but I can testify that I don't regret my decision one bit.
Post edited December 26, 2013 by UniversalWolf
I haven't beaten it yet (Going through System Shock first before continuing on the second, it's a personal quirk of mine to go in order for many video game series...) and I have yet to experience quite a lot of it, but I will say though that those darn monkey enemies make me lose it every time I see them. It's just that they use these sound library monkey noises that I have always heard in various cartoons growing up, and it is hard to take them seriously with those noises being associated to light hearted stuff I have viewed.