Yes, the game is for Windows 10 only, but i was able to run it in Windows 7 using DXVK. So a workaround is possible.
Other differences :
The game resolution if fixed, matching the desktop res. The option was available in the old game but removed in the new.
The menu music was changed. It was mr.Sandman (or lollipop, don't remember well) in the old game and a generic rock music in the new.
On the good side, subtitles has been added and there is an option to multiply the internal resolution (up to 400x).
I'm still early in the game, so i don't know if there are others differences.