Anyone else had this issue? Tried compatibility mode with 7 and it didn't have any effect.

xrEngine.exe caused BREAKPOINT in module "D:\Games\S.T.A.L.K.E.R. Clear Sky\bin\xrCore.dll" at 0023:02B3B944, xrDebug::backend()+164 byte(s)

Specs:
ASUS Crosshair VI Hero WiFI
AMD Ryzen R7 1800X
2x8GB G.Skill Flare DDR4-3200
Sapphire Radeon Fury Nano with latest drivers
Samsung 960 Pro 500GB NVMe SSD, 2x Samsung 850 EVO 1TB SSD
Windows 10 Professional 1709

Yes I have the same issue.
My specs are very different, though.

Operating System: Windows 7 Home Premium 64-bit (6.1, Build 7601) Service Pack 1
Motherboard: Gigabyte P55A-UD3
Processor: Intel(R) Core(TM) i5 CPU 760 @ 2.80GHz (4 CPUs), ~2.8GHz
Video Card: NVIDIA GeForce GTX 950

I see one common thing: we both have our game stored on the D: drive.

I had the same problem. It turn out to be a problem with MSI Afterburner and Rivatuner running when I was starting the game in dx10. For some reason it will only run in dx9 with those two programs running as well.

I am in exactly the same boat, if anyone has any ideas/updates i'd love to know.

Processor Information:
CPU Brand: Intel(R) Core(TM) i7-4790K CPU @ 4.00GHz

Operating System Version:
Windows 10 (64 bit)

Video Card:
Driver: NVIDIA GeForce GTX 970
GameReadyDriver: v417.71
Driver Version: 25.21.14.1771

Primary Display Resolution: 2560 x 1440
Desktop Resolution: 2560 x 1440

Memory:
RAM: 16326 Mb

Replacing the fsgame.ltx contents with this fixed the issue. Can't enable DirectX 10.1, but I'm guessing it's a limitation of the game running on a DirectX 12 system.

So glad it worked for you.
Did your keyboard just work for you or did you have to do anything?
Mine still won't work with the game. I've never had a problem with the keyboard before and it works again as soon as I alt-tab out of the game to desktop, so it seems to be just the game not seeing it.
Grrrrr.

My keyboard doesn't work, and it doesn't even work after alt-tabbing. May have to be that I have it in a USB 3.0 slot but I doubt it.

I've figured out the keyboard problem!
Steam to the rescue again, i found the user config file for clear sky user.ltx in STALKER Clear Sky\_appdata_
It has no keybindings in it.
If you copy this user.ltx file from my Steam version into the GoG one it has the key bindings in.


_preset Extreme
ai_use_torch_dynamic_lights on
bemsg 1
unbindall
bind left kLEFT
bind right kRIGHT
bind up kUP
bind down kDOWN
bind jump kSPACE
bind crouch kLCONTROL
bind accel kC
bind sprint_toggle kLSHIFT
bind forward kW
bind back kS
bind lstrafe kA
bind rstrafe kD
bind llookout kQ
bind rlookout kE
bind cam_zoom_in kADD
bind cam_zoom_out kSUBTRACT
bind torch kL
bind night_vision kN
bind show_detector kO
bind wpn_1 k1
bind wpn_2 k2
bind wpn_3 k3
bind wpn_4 k4
bind wpn_5 k5
bind wpn_6 k6
bind artefact k7
bind wpn_next kY
bind wpn_fire mouse1
bind wpn_zoom mouse2
bind wpn_reload kR
bind wpn_func kV
bind wpn_firemode_prev k9
bind wpn_firemode_next k0
bind pause kPAUSE
bind drop kG
bind use kF
bind scores kTAB
bind chat kCOMMA
bind chat_team kPERIOD
bind screenshot kF12
bind quit kESCAPE
bind console kGRAVE
bind inventory kI
bind buy_menu kB
bind skin_menu kO
bind team_menu kU
bind active_jobs kP
bind map kM
bind contacts kH
bind vote_begin kF5
bind vote kF6
bind vote_yes kF7
bind vote_no kF8
bind speech_menu_1 kZ
bind use_bandage kRBRACKET
bind use_medkit kLBRACKET
bind quick_save kF5
bind quick_load kF9
bind alife_command kK
cam_inert 0.
cam_slide_inert 0.25
cl_cod_pickup_mode 1
cl_dynamiccrosshair on
con_sensitive 0.15
draw_downloads 1
g_always_run on
g_autopickup on
g_backrun on
g_corpsenum 10
g_dynamic_music on
g_eventdelay 0
g_game_difficulty gd_stalker
hud_crosshair on
hud_crosshair_dist off
hud_info on
hud_weapon on
mm_mm_net_srv_dedicated off
mm_net_con_publicserver off
mm_net_con_spectator 20
mm_net_con_spectator_on off
mm_net_filter_battleye on
mm_net_filter_empty on
mm_net_filter_full on
mm_net_filter_listen on
mm_net_filter_pass on
mm_net_filter_wo_ff on
mm_net_filter_wo_pass on
mm_net_srv_gamemode st_deathmatch
mm_net_srv_maxplayers 32
mm_net_srv_name Stalker
mm_net_srv_reinforcement_type 1
mm_net_use_battleye on
mm_net_weather_rateofchange 1.
mouse_invert on
mouse_sens 0.12
net_cl_icurvesize 0
net_cl_icurvetype 0
net_cl_interpolation 0.
net_cl_log_data off
net_compressor_enabled 0
net_compressor_gather_stats 0
net_dbg_dump_export_obj 0
net_dbg_dump_import_obj 0
net_dbg_dump_update_read 0
net_dbg_dump_update_write 0
net_dedicated_sleep 5
net_sv_gpmode 0
net_sv_log_data off
net_sv_pending_lim 3
net_sv_update_rate 30
ph_frequency 100.00000
ph_iterations 18
r1_dlights on
r1_dlights_clip 50.
r1_fog_luminance 1.1
r1_glows_per_frame 16
r1_lmodel_lerp 0.1
r1_no_detail_textures off
r1_pps_u 0.
r1_pps_v 0.
r1_ssa_lod_a 64.
r1_ssa_lod_b 48.
r1_tf_mipbias 0.
r2_aa off
r2_aa_break 0.000000,1.000000,1.000000
r2_aa_kernel 0.5
r2_aa_weight 0.250000,0.250000,0.000000
r2_allow_r1_lights off
r2_detail_bump on
r2_dof -1.250000,1.400000,600.000000
r2_dof_enable on
r2_dof_kernel 5.
r2_dof_sky 30.
r2_exp_donttest_shad off
r2_gi off
r2_gi_clip 0.001
r2_gi_depth 1
r2_gi_photons 16
r2_gi_refl 0.9
r2_gloss_factor 4.
r2_ls_bloom_fast off
r2_ls_bloom_kernel_b 0.7
r2_ls_bloom_kernel_g 3.
r2_ls_bloom_kernel_scale 0.8
r2_ls_bloom_speed 100.
r2_ls_bloom_threshold 0.2
r2_ls_depth_bias -0.0003
r2_ls_depth_scale 1.00001
r2_ls_dsm_kernel 0.7
r2_ls_psm_kernel 0.7
r2_ls_squality 1.
r2_ls_ssm_kernel 0.7
r2_mblur 0.
r2_parallax_h 0.02
r2_slight_fade 0.5
r2_soft_particles on
r2_soft_water on
r2_ssa_lod_a 64.
r2_ssa_lod_b 48.
r2_ssao st_opt_high
r2_ssao_blur off
r2_ssao_half_data on
r2_ssao_hbao off
r2_ssao_hdao off
r2_ssao_opt_data off
r2_steep_parallax on
r2_sun on
r2_sun_depth_far_bias -0.00002
r2_sun_depth_far_scale 1.
r2_sun_depth_near_bias 0.00001
r2_sun_depth_near_scale 1.
r2_sun_details off
r2_sun_far 100.
r2_sun_focus on
r2_sun_lumscale 1.
r2_sun_lumscale_amb 1.
r2_sun_lumscale_hemi 1.
r2_sun_near 16.
r2_sun_near_border 0.75
r2_sun_quality st_opt_high
r2_sun_shafts st_opt_high
r2_sun_tsm on
r2_sun_tsm_bias -0.01
r2_sun_tsm_proj 0.3
r2_tf_mipbias 0.
r2_tonemap on
r2_tonemap_adaptation 1.
r2_tonemap_amount 0.7
r2_tonemap_lowlum 0.0001
r2_tonemap_middlegray 1.
r2_volumetric_lights on
r2_wait_sleep 0
r2_zfill off
r2_zfill_depth 0.5
r2em 2.2
r3_dynamic_wet_surfaces on
r3_dynamic_wet_surfaces_far 30.
r3_dynamic_wet_surfaces_near 10.
r3_dynamic_wet_surfaces_sm_res 256
r3_gbuffer_opt on
r3_minmax_sm autodetect
r3_msaa st_opt_off
r3_msaa_alphatest st_opt_off
r3_use_dx10_1 on
r3_volumetric_smoke on
r__detail_density 0.2
r__dtex_range 50.
r__geometry_lod 1.
r__supersample 1
r__tf_aniso 16
r__wallmark_ttl 60.
renderer renderer_r2.5
rs_c_brightness 1.
rs_c_contrast 1.
rs_c_gamma 1.
rs_cam_pos off
rs_fullscreen on
rs_refresh_60hz off
rs_skeleton_update 32
rs_stats off
rs_v_sync off
rs_vis_distance 1.
snd_acceleration on
snd_cache_size 32
snd_device Generic Software
snd_efx on
snd_targets 32
snd_volume_eff 1.
snd_volume_music 1.
sv_activated_return 0
sv_anomalies_enabled 1
sv_anomalies_length 3
sv_artefact_respawn_delta 30
sv_artefact_returning_time 45
sv_artefact_spawn_force 0
sv_artefact_stay_time 3
sv_artefacts_count 10
sv_auto_team_balance 0
sv_auto_team_swap 1
sv_bearercantsprint 1
sv_client_reconnect_time 60
sv_console_update_rate 1
sv_dedicated_server_update_rate 100
sv_dmgblockindicator 1
sv_dmgblocktime 0
sv_dump_online_statistics_period 0
sv_forcerespawn 0
sv_fraglimit 10
sv_friendly_indicators 0
sv_friendly_names 0
sv_friendlyfire 1.
sv_hail_to_winner_time 7
sv_invincible_time 5
sv_max_ping_limit 2000
sv_pda_hunt 1
sv_reinforcement_time 0
sv_remove_corpse 1
sv_remove_weapon 1
sv_returnplayers 1
sv_rpoint_freeze_time 0
sv_saveconfigs 0
sv_savescreenshots 0
sv_shieldedbases 1
sv_show_player_scores_time 3
sv_spectr_firsteye 1
sv_spectr_freefly 0
sv_spectr_freelook 1
sv_spectr_lookat 1
sv_spectr_teamcamera 1
sv_statistic_collect 1
sv_teamkill_limit 3
sv_teamkill_punish 1
sv_timelimit 0
sv_vote_enabled 255
sv_vote_participants 0
sv_vote_quota 0.51
sv_vote_time 1.
sv_warm_up 0
texture_lod 0
vid_mode 1920x1080
wpn_aim_toggle 0

Okay, follow all the instructions above if you need to but the weirdest thing has just happened.
I've just uninstalled and reinstalled the game (for about the 6th~ time) to see if following my instructions works and to make sure all of this works and to check it wasn't down to further fiddling about.

Just to see what would happen i thought i'd try to start the game and it started!!
The fsgame.ltx file has populated differently. You'll note that the lower 5 lines are now like a merged version of the GoG and Steam version of the code and that the app_data_root is now a file path. I've changed my username to USERNAME for where yours would go.

;abbreviation = recurs|notif| root| add| ext| description
$arch_dir$ = false| false| $fs_root$
$game_arch_mp$ = false| false| $fs_root$| mp\
$arch_dir_levels$ = false| false| $fs_root$| levels\
$arch_dir_resources$ = false| false| $fs_root$| resources\
$arch_dir_localization$ = false| false| $fs_root$| localization\
$arch_dir_patches$ = false| true| $fs_root$| patches\
$game_data$ = false| true| $fs_root$| gamedata\
$game_ai$ = true| false| $game_data$| ai\
$game_spawn$ = true| false| $game_data$| spawns\
$game_levels$ = true| false| $game_data$| levels\
$game_meshes$ = true| true| $game_data$| meshes\| *.ogf;*.omf| Game Object files
$game_anims$ = true| true| $game_data$| anims\| *.anm;*.anms| Animation files
$game_dm$ = true| true| $game_data$| meshes\| *.dm| Detail Model files
$game_shaders$ = true| true| $game_data$| shaders\
$game_sounds$ = true| true| $game_data$| sounds\
$game_textures$ = true| true| $game_data$| textures\
$game_config$ = true| false| $game_data$| configs\
$game_weathers$ = true| false| $game_config$| environment\weathers
$game_weather_effects$ = true| false| $game_config$| environment\weather_effects
$textures$ = true| true| $game_data$| textures\
$level$ = false| false| $game_levels$
$game_scripts$ = true| false| $game_data$| scripts\| *.script| Game script files
$app_data_root$ = true| false| C:\Users\USERNAME\DOCUME~1\STALKE~3
$logs$ = true| false| $app_data_root$| logs\
$screenshots$ = true| false| $app_data_root$| screenshots\
$game_saves$ = true| false| $app_data_root$| savedgames\
$downloads$ = false| false| $app_data_root$

I didn't even have to paste in the user.ltx to fix the keys.

Just to reiterate, this time i did nothing but reinstall the game after fully deleting save files etc as well.
I didn't copy anything or change any files.

Well i'm going to play some stalker and see how it goes.

HOLY SHIT, Finally, Thank You.

I had the same issue.
First I tried reinstalling the game. But that didn´t solve the problem.
Then I only deleted "user.ltx" and the game started. I had to set the keybindings again ("Options"->"Controls"->"standard").

Dude u are the real MVP!

Hello, could you tell me how to switch to dx9? i searched a way to do it and can´t find one