Running Deadire from its shortcut/exe will not load any installed DLC, it has to be run from within GOG Galaxy every time. I tried installing the DLC again from the manual EXEs provided in my account downloads, it still refuses to run unless GALAXY is used to launch the game.

Running this game from GOG Galaxy seems to disable any installed mods.

Doesn't matter if you place them in exported/design/gamedata folder or the override folder, or a structure matching set of nested folders in the override.

All three install methods of mods worked when launched from the exe/shortcut. As soon as I load the game from GOG Galaxy the game ignores any installed mods.

Its worth mentioning here too that any game saved with active DLC will refuse to load if access to said DLC is removed (Say if you load the game from the shortcut/exe).

Last new title I buy here.

I have to cop to this being my fault. Sorry Galaxy.

Somehow windows 10/Galaxy decided that my backup copy of the game on my regular media E:\ was where the installtion was for updating and DLC. Not the installation on my SSD where I was manually installing mods.

I was running two copies without realising it. Official stuff going to my backup on E:\ and running that copy from Galaxy, and the copy on my SSD getting just the manually installed mods. Galaxy wasn't removing the mods or preventing them loading, it just couldn't see them.