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I don't know if this is still a problem for some but I haven't seen my solution yet.

With an nvidia card you can use NVIDIA Inspector, a powerful tool to change the settings of all nvidia graphics profiles for games. Just google it.
When you've got it running click on the little tool icon next to the line with the driver version. Select the profile for Painkiller and find the line "Frame Rate Limiter". Here you can set the fps the game will run at. You will notice that at certain numbers it will say "reduces inputlag on vsync xxHz". These are the ones you should select, well, one of them, depending on the refresh rate of your monitor.
After that, find "Vertical Sync" a little bit lower and select "Force on" to force vsync ingame if you haven't done that already.
I still have Triple buffering enabled but I don't know if that's doing anything.

Anyhow, with these settings I can play with vsync on and don't experience any inputlag.
The loading time bug seems to have been fixed in the gog update.

I hope this still helps someone out there.
avatar
JohnnyCash:
nevermind. I see now that you know about the update.
Post edited January 07, 2013 by Kank
Hi,

I'd like to know, how do you force v-sync with an AMD card (Radeon HD 7870) ? I don't want my card to heat uselessly !

I put the slider on "Always on" in the Catalyst Control Center, but it does not work for Painkiller. The setmaxfps does the job, but of course I get tearing... and you have to use the command everytime you run the game