Since this is my favourite game I have decided to aggregate all the necessary information on how to run this game in modern macOS without depending on the GOG version of the game.

If you would like to experience Lands of Lore: Guardians of Destiny with the 3dfx Voodoo emulation on newest macOS Sequoia, take a look at my guide: https://mattkomarnicki.com/articles/running-lands-of-lore-guardians-of-destiny-on-macos-sequoia-with-3dfx