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I have created a video guide for how to get Interstate '82 running on Windows 10 64-bit, this fix helps with some soundtrack issues as well.

Here is a link:
https://www.youtube.com/watch?v=xFNHJEJO3UM
Oh man, this actually works!

Shame the game doesn't support anything higher than 1280x1024. Would have been nice to play in 1600x1200.