I looked around on the GOG forum, and there are posts about using a controller. There were some pictures about the control profiles, and they look good, but I didn't tried them so far.
A controller have two analog sticks (can also function as buttons) that can be controlled by thumbs, and there are 8 buttons and a D-pad.
I tried it in a couple of flight simulators, and they are better than the keyboard and mouse combo, but a joystick is different in the aspect, that it is directly designed to be used in flight and space simulators (and in older Mechwarrior games, as I heard).
I only wonder, how different experience the joystick is compared to the controller.