PresidentKoopa: Deus Ex? Easy. The knife. That piece of crap knife and it's serrated edge have bugged me since the day of release. The model isn't serrated, the skin is drawn to make it look so, with black triangles resulting on the side. This is always broke immersion for me.
Not the most game breaking thing, maybe, but you said it's a hard game to improve.
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I would have liked, though, to have a smarter inventory system. Something which can either adapt to your preferred items or allow you to customize something like not picking up the knife off of every person you search. Every time I loot someone I have to drop a knife, or a baton, or cigarettes, or zyme... well... maybe not zyme.
*shoots up*
[edited for tyops]
:)) zyme.. Ok .. this might be a bit too much detail .. the knife model thing .. but if it was bad for you .. you had to say it ! I personally LOVED the x-bow in this game .. so never used the knife much.