JudasIscariot: I haven't experienced the mission loading issue or the mouse cursor issue. You're playing the game on a clean prefix, I presume?
Are you starting the game via terminal? Perhaps there's some terminal output that can be of use for Bugzilla :)
Matruchus: Yes, im playing the game on a clean prefix. Had the same issue in stock wine version for Linux Mint before. Starting it graphically.
Start it via terminal "wine HeroesOfAE.exe" and you should see a lot of output in the terminal. That output might be useful in case you decide to file a bug report in Bugzilla about it :)
In my terminal I see a lot of
fixme:d3d:wined3d_check_device_format_conversion wined3d 0x1ffaf0, adapter_idx 0, device_type WINED3D_DEVICE_TYPE_REF, src_format WINED3DFMT_B8G8R8X8_UNORM, dst_format WINED3DFMT_B5G6R5_UNORM stub!
but I have a slightly older version of Wine so your output may vary :)