Thanks, deleted the folder and did a clean install (GOG first than subtitle patch) but still won't work :(
Do I use a specific .exe file to run it?
No interleave seems to work though.
When you install the subpatch, are you pointing it at the GOG installation directory?
Unless you changed it, the game will be located at:
32-Bit Windows: C:\Program Files\GOG.com\Gabriel Knight 2\
64-Bit Windows: C:\Program Files (x86)\GOG.com\Gabriel Knight 2\
If you are doing this by browsing there, make sure to remove the \GK2 that it adds.