Originally owned on steam, when my old HDD went phut and was replaced I was unable to get back into steam. Waited and finally it arrived here - but not for my old XP system. (On the same day as it was released by GoG they dropped XP support. Talk about up and down.
When I bought my shiny new rig (Win7 etc) FNV was one of the first games I bought. It ran, with success. I experienced the infinite loading bug twice, and it crashed once while entering a new location. Otherwise, all went well. 135 hours, so the few hiccups weren't problematic.
Just to let people know, it does work, unmodded, and after several years of waiting, I completed it with all DLC's.
So it took several years and old man style patience, but I got there.
.....at the end of the hoover dam battle the game ends. Complete everything else before you set off on this one. You are given fair warning though.