I'm using Debian Sid and with the recent update to Wine 3.0, I had to have a look in the Wine configuration to fix new errors occuring at runtime, usually triggered by selecting the Mojave music radio.
Concerning my Fallout New Vegas environment, I run it with Wine's virtual desktop activated, I use a GPU with the radeon driver provided by my distribution, and everything is working well, modulo the fact that:
- with Wine 2.0.4, I had to disable winegstreamer for proper game execution,
- with the upgrade to Wine 3.0, I also had to disable mshtml and mscoree.
I am testing these settings in a clean Wine prefix at the moment to ensure the modifications are necessary, sufficient and working (virtual desktop seems necessary in my case), as I tidied a bit my main prefix with Winetricks. B-)
So far, so good... I hope this helps if anyone is running into troubles.