has anyone tried this? i have an installer that can install a retail cd and shareware but it wont recognise the downloaded file. if anyone has done this succesfully or knows how to take the download and make it look like a retail disc please help.

Since there is nearly no instructions on how to play this game on Mac OS X on the internet I will describe it.

There are two ways: Boxer (DOSBox implementation for Mac) and EDuke32. I will be describing Boxer first and EDuke some other time.

Preparations
You will have to do the following whether you use boxer or EDuke32
Download Duke Nukem 3D form GoG.
Now we need to install the game somehow. use a Windows PC, a BootCamp partition, a virtual machine, Crossover or, my favourite, Wineskin. Wineskin is free and all we need to do is just install the game, not run it, so any of these will do.
Now that you have installed the game go to the folder you installed it to (e.g. C:\Program Files\GoG.com\) and put the "Due Nukem 3D" folder somewhere on your Mac. You can throw away the rest of your installation away now.

Now that we have the game's folder it#s time to get it running

Boxer

You can get Boxer at
http://boxerapp.com/

Download it, put it somewhere on your hard drive (Applications folder recommended) and launch it once.

Remember the folder we prepared in the last post? Add the extension ".boxer" to it (e.g. "Duke Nukem 3D.boxer")

Congratulations, you have created a ready-to-use gamebox. Now all you have to do is double-click and play it. Well, usually that would be all, but Duke Nukem 3D still needs some settings.

Launch "Duke Nukem 3D.boxer" and you will see a DOS prompt. At the bottom of the windows you will see abunch of executables. To the far right there is "setup.exe". Click it.

Now you can see the setup screen. It is its own appliction, unlike today#s games where the configuration is done in-game.

Choose "Sound Setup", then choose "Setup Sound FX Card". Select "Sound Blaster"

In the following "Window" make sure adress is set to "0x220", Interrupt is "7", 8-bit DMA is "1" and 16-bit DMA is "5"

The "use these settings and continue", number of voices is 8, 8-bit mixing, and the rest is fine as it is.

Now we could play the game, but while we're at it we can change the controls to be more like modern FPS. I included an image file that shows how I set up my mouse and keyboard. It's the same control scheme EDuke32 uses.

Exit the setup, save the changes when asked and you will find yourself at the main DOS prompt. Among the executable at the bottom choose "duke32.exe" to play the game. Boxer will ask you if you want to launch duke3d.exe every time, say yes if you want to. Then you won't have to select duke32.exe every time you launch "Duke Nukem 3D.boxer"

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That's it, you now have a fully working authintic DOS version of Duke Nukem 3D. You can still customize the gamebox, like adding an icon and so forth. There is enough information on that at Boxer's website.
Have fun.
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I will put the EDuke32 instruction here ventually. In the meantime there is a YouTube video that has a link for intstruction in its description. I used it to set up my game, but it's not well written, that's why I want to writ the instructions here

http://www.youtube.com/watch?v=epnU0FxFLy4

Sorry for the 12 year long reply, but I stumbled across this post (thanks for helpin everyone who has sucessfully gotten Duke Nukem 3D on their Mac, even me), but about one of the files you mentioned, the "EDuke.cfg" file, that doesn't appear inside ~?Library?application Support/Eduke32. I was just wondering what's going on. but anyways thanks for helpin us lad!!!