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Calm, Patience, and Read on;

The primary cause for CTD after Quick Start or Launcher Activation is an issue with the game's Startup.ini

To fix this, proceed to the Game's Directory on your computer... Open the Startup.ini and change playmovie 1 to playmovie 0.

The Game also requires DirectX, Microsoft XNA 4, and Net Framework for Microsoft. All of which you should have in a standard installation of Windows 10.
Thank you. This really should be something that GoG addresses so it's fixed out of the box