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This works really easy but there's one gotcha, so I might as well send it here.

If you want to aim with the right mouse button as we're used to, use this Autohotkey script

SendMode Input
SetWorkingDir %A_ScriptDir%

#SingleInstance force

Run C:\Games\Deadly Premonition\DP.exe
#IfWinActive, Deadly Premonition
RButton::Space
Change the install path to Deadly Premonition according to your settings.

The WSAD keys are not remappable. Here's a script for ESDF movement:

SendMode Input
SetWorkingDir %A_ScriptDir%

#SingleInstance force

Run D:\Games\Deadly Premonition\DP.exe
#IfWinActive, Deadly Premonition
RButton::Space
e::w
s::a
d::s
f::d
Note: If you want to start the launcher instead of the game itself, you must run the script as administrator, otherwise it won't work.
Post edited November 05, 2013 by Revisor
No rebindable keys: facepalm.

Thanks for the heads up, passing.
I'll try this.
Here is my autohotkey script. It uses the arrow keys to steer, the right shift to run, mouse right to draw and aim, ctrl right to hold breath, middle mouse button to look, the end key (above the arrow keys) to put something in the inventory and the fourth mouse button to return/escape. After finishing the game you just need to press escape to close ahk completeley. I did not manage to let it close automatically (tried for a few hours).

Run, E:\Deadly Premonition\DPLauncher.exe
esc::exitapp

#IfWinActive, Deadly Premonition

up::w
down::s
left::a
right::d

RButton::Space
Mbutton::C
Numpad0::E
XButton2::R
end::f

Rcontrol::Lcontrol
RShift::LShift
Thank You Based Marko
Cool fix, but how do I apply it? Do I need some external program for it or do I just create a txt file? I have never heard of this Autohotkey before.