Andrea1988: Try this:
- Uninstall CC2
- Remove CC2 registry keys with regedit (I think that this is the most important step)
- Install to default GOG Games folder in C: drive
I had your issue and solved it in 3 Windows 10 machines and another user in a similar topic has solved the issue by following these steps, try it and this should fix it
G2G_School: Still new to the site, what exactly to do mean by uninstall the registry keys? My crashing issue has expanded to almost every campaign after completing a successful mission. Plese help! Love this game and hate to see it crash every time I start a new file only to have it get stuck only a mission or two in.
He means that you need to manually delete the registry keys for CC2. This is done by starting Regedit, finding the appropriate key and then deleting it. However, if you're unfamiliar with doing this kind of thing then beware that you can mess up Windows if you delete or change the wrong things.
I'm not sure where the GOG version stores the game's registry keys, but the original Microsoft retail version stored them here:
HKEY_LOCAL_MACHINE\SOFTWARE\WOW6432Node\Microsoft\Microsoft Games\Close Combat\2.00
Search the Registry for "Close Combat" to find where yours are.