So, that's an issue I already encountered a year ago when playing the Windows version of Carmageddon, now I'm also having the same issue with Carmageddon II. When I exit the games and return to the desktop mouse clicks aren't recognized anymore. I can still move the mouse cursor around and everything else seems to work fine but I always have to reboot if I wish to make the mouse buttons work again.

Anyone else run into this issue? Anybody have a solution to make the mouse work again without having to reboot?

Running it on Windows 7 64 bit btw..

I ran into a similar problem with playing Fallout 2 (and it wouldn't even run), the solution was to rename the executable, maybe this works here as well.
I also think it was not so much that the mouse didn't work but that is was some sort of compatibility layer that wouldn't go away and prevented doing anyting with the desktop.

Yeah, I'm presuming the same thing, that there's come process that intercepts the mouse input and doesn't disappear when it should. If so: I am unable to identify the process. Would just friggin' love if someone were able to tell me which one it is.

Edit: Correction - the right mouse button is recognized. It seems only the left button stops working, not sure about the mouse wheel.

I know this is an old discussion, but I have encountered this problem with Carmageddon 2 as well and this is the only place I have found anyone discussing it. I was disabling potential culprits one by one and the problem went away when I killed Wacom graphics tablet services. I haven't updated my Wacom software for quite some time, so the bug may be fixed by now. Hopefully someone finds this helpful.

Killing the wacom services worked for me as well (which is weird since I didn't experience the same problem with Carmaggedon Max Pack). Thanks a lot, friend.