My advice would be to patch it with the official patch before playing; play it through a few times, to get the feel for the game as released; then add Drog's unofficial Arcanum patch (and the HQ town maps, and maybe even the level 50 crack) to up your gaming experience.

The UAP fixes a huge number of bugs (unusable schematics, broken or nonexistent dialog options, duplicate images for different items) but also removes a few of the in-game exploits (extra Fate points for certain courses of action, a permanent magical boost from equipping a specific cursed item). It'll be your call which way the game plays better for you.