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I had massive Problems getting the Sound to work on this Title. Strangely, it worked in the Intro-Video but not in the Game itsself.
Changing Soundcard-Settings in the Game's Setup only crashed the Game!

Solution: You'll need another Version of the DOS4GW-FIle. The one provided with the Game doesn't work! For me, the one from the Game BLOOD worked (it's the Version 1.97; you'll see it when the Game starts). Now setting the Game to Soundblaster-Sound should get it done. (There's a Config-File in the "Tower"-Subdir where you can check the Devices for the Game) .
A Soundbalster 16 in Dosbox worked for me.

Additionally, I reduced the Blocksize to 512 and the Prebuffer to 20 'cause of lagging Sfx and pushed the Cycles to 7500, so the Game ran smoothly...
Post edited January 06, 2016 by Hoessi666
This post should be highlighted. I was looking for this literaly during years!
To add some further information.

I test a lot of GOG DOSBox games on a real DOS PC, it's sort of a hobby for me :)

So when you run SETSOUND to change the sound options, it throws an error.

You need to grab TA.CFG from the sub-directory and move it to the main directory. Then SETSOUND will work. You can also just manually configure TA.CFG.
I use DOSBOX CRT for most GOG DOS Games as it has a built-in shader which makes blocky games look much better. https://mattiasgustavsson.itch.io/dosbox-crt

I know there are other DOSBOX versions that support shaders. DOSBOX X, DOSBOX ECE, DOSBOX SVn & DOSBOX Staging. All work great with Alien Breed.

Here are my sound settings (TA.cfg) for Gravis Ultrasound,

SOUND ULTRA

MUSIC 1
EFFECTS 1

SB 220 5 1
SBPRO 220 5 1
SB16 220 5 1
PRO 220 5 1
PRO+ 220 5 1
PRO16 220 5 1
WSS 220 5 1
ULTRA 240 5 1

TSENG 1
DEBUG 0
Post edited November 22, 2021 by chockimon