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Gifting of The Witcher 3: Wild Hunt temporarily unavailable (fix in progress)GOG Galaxy - troubleshooting and useful informationThe Witcher 3 predownload - frequently asked questionsNvidia code for The Witcher - common issues and solutions
Try disabling the “enhance pointer precision” option. To do this, go to Start -> Control Panel -> Mouse -> Pointer Options, then make sure that “Enhance pointer precision” is un-checked, and click OK.
This should fix typical DOSBox mouse issues.