I am having trouble on Windows XP with the known "Police Station" crash bug (see http://www.longestjourney.com/help/faq/knownbugs/police.html).
Basically, I forgot an item and had to re-enter the police station after getting in the first time using the garbage truck. The only way to re-enter is through the front doors, where the game crashes. I attempted to download the patch above and it would not install due to missing registry keys (which I presumed was due to the GOG installation). I also attempted to disable hardware acceleration using the preferences.ini change to no avail.
Any suggestions would be appreciated! Thanks in advance!