Same here. It's not the end of the world to just save regularly and seems to become more stable with time... It's good general adventure-game practice to get used to in any case, a game can crash for any number of reasons.
Just to let you know: I've managed to play through Sanitarium. I found that saving often reduces the crash rate a lot! I've just played the last two chapters for about 2 hours and it didn't crash once.
If you save after every major accomplishment, you should be safe. And if not: at least you won't have to do a lot of stuff a second time ;)