There were two points in the game where Ed would lower his head just before a fade to black scene transition that caught my attention. The kiss at the baseball field is one of them, but the first was at the end of the very first scene as Ed finishes the phonecall with Dr. Morales. It made me think Ed had black outs, perhaps from having multiple personalities, and it made me consider that 'unreliable narration' was going to become a big thing later in the story. I felt that the game was lingering on those two transitions to set up up a twist where these blind spots would be filled in.
Things turned out much less complicated than that, but I wasnt completely off mark. I still did not predict how tragic the reveal would turn out and I dont think anyone could have guessed what was going to happen even with all clues pointed out. Not until Ed took the gun, that is.