I mentioned before I agree with the frustrating hit-or-miss platforming during the last stage of Valdis Story, but that was a "light nope" moment. I managed to finish and largely enjoy the game. Most games that had "nope" moments, for me, are games I gave up on due to those same moments.
I don't get scared by video games, so monsters and jump scares are far from being "nope" situations (not saying this in any macho way, it just happens that I got desensitized by watching way too many horror movies when I was a kid; horror in media doesn't scare me anymore).
My most recent memory of a huge NOPE was when I listened to the Shadow Gun sound effect in Shadow Man
. Nope. I can't endure a whole game of that. I guess I got past the first area, got some sort of upgrade, but that gunshot sound was driving me nuts and I just called it quits.
Other "nope" moments usually happen when some mechanic is broken, or if I thought a game was real time but turns out to be turn-based. NOPE. No way in hell I'm playing those.