The only thing you miss out on is "exclusive content" - but it is generally trivial stuff of little value after a few minutes play time.
And before anyone says I'm not supporting the Games Industry by not buying on day one - bah, I spent about 20+ years buying games at full price - its payback time. Indies are different, I don't mind buying them at full price now and then - since their starting price is more reasonable anyway.
At the moment I am more concerned with content only available to online players and single player games being trimmed down to almost nothing because "everyone plays online now, you know".
P.S. I just realised that there is a potential market for my buying strategy with like minded individuals. I think I'll start a web site for it - maybe called "Fine Aged Games" or some such.