Sequential Art (awesome - start at beginning and give it a few (short) strips)
How to Play...(game related)

both on:
http://www.collectedcurios.com/

And of course: The most awesome comic ever made about a troll who accidentally became a wise-sage (though, admittedly, that's a small niche)

Trollum Thinks and
Trollum Finds a Girl

both on:
http://www.foolsisland.com/silentwinter

Giving this a bump to say that
a) Order of the Stick is awesome and...
b) ... currently doing a reprint drive on kickstarter: http://www.kickstarter.com/projects/599092525/the-order-of-the-stick-reprint-drive
Unfortunately, the only way to pay seems to be credit card. No more details for now because I'm tired ;)

My first webcomic was... 8-Bit Theatre, as I recall.

The ones I read regularly are:

-nuklearpower.com (all of their comics)
-Ctrl+Alt+Del (mostly force of habit)
-Order of the Stick
-Questionable Content
-xkcd
-Least I Could Do
-Penny Arcade
-The Trenches (Penny Arcade/PvP sister work)
-The Noob Comic/Clichéquest
-Dark Legacy Comics
-Sluggy Freelance
-Schlock Mercenary
-Homestuck (or, for future reference, whichever the active adventure is on MSPA)
-Sweet Bro and Hella Jeff (hte tatoly awsumet wbecomic of all tTIME & its on MSPA)

I strongly recommend Homestuck; it's... well, it's a great example of what a web comic should be. It makes great use of the medium, delivering not only comics but also music, animations, website manipulation, etc.; basically, all the available tools of the Internet.

It's quite rare to see a webcomic truly utilize its medium; I only recall reading one other comic where this was made the central point: The Concuspidor, one of the earliest webcomics online. I strongly recommend checking it out; its writing is clever, and the history behind it is fascinating to those of us who weren't adults back when the Internet was new. For that matter, make sure you take a look at Planetarium, a browser game by the same creator(s) which is very close to the comic in execution.

Stuff I've read in the past, or read irregularly, and which I can recommend:
-Problem Sleuth (the first major MSPA adventure)
-Gunnerkrigg Court (absolutely fantastic)
-Girl Genius (for some reason it doesn't endear itself to me very much)
-Ratfist (by Doug TenNapel, the dude who did the Earthworm Jim art)
-Freakangels (by Warren Ellis!)
-Shortpacked! (too many toy jokes for me)
-Looking For Group (I prefer saving up a large chunk of pages so they have time to do the colouring)
-The Adventures of Dr. McNinja (too much action to be read one page at a time)
-Dresden Codak (it updates?)
-The Perry Bible Fellowship
-Bruno the Bandit (still got about half the archive left; I hear the artist had to quit due to health reasons and the comic not being profitable)
-Rob & Elliot (wonderfully strange sense of humour; did weekend strips for Sluggy Freelance for a while)
-Sequential Art (I have no idea why I read this, but I suppose it might warrant inclusion on the list)
-Cyanide & Happiness
-Saturday Morning Breakfast Cereal
-Oglaf (WARNING: NSFW. Extremely well-drawn, funny and clever, but also borderline pornographical; actually, scratch "borderline")
-The Non-Adventures of Wonderella (remarkably, its artwork has stayed completely consistent during its entire run)

That's... all I can think of right now. I'm sure a few more will pop into my head as soon as I switch off the computer, though.
I have no idea how such a remarkably tasteless comic manages to be so completely inoffensive. Something about the drawing style, I think. But, seriously, don't read it near other humans, sentients, mammals or vertebrates.

My first was Sluggy Freelance, along with 8-bit Theater and Ozy and Millie. I guess that was about 10 years ago now, jeez! I quit reading them in college, and have only started reading a few more recently. Mostly Homestuck, xkcd, and Order of the Stick. The only one I really follow often is Homestuck, though, because it updates like 5 times a day, which is just absurd. I guess I got spoiled by Sluggy Freelance, which would have a new comic EVERY SINGLE DAY, with almost zero exceptions, even if the author was on vacation or deathly ill. As much as I love Order of the Stick, its "update schedule" means I only check it about once a month.

Servants of the Imperium?

xkcd
Penny Arcade
Megatokyo

sounds familiar

definitely dr. mcninja, xkcd, and perry bible fellowship as well

School Spirit - the Web Comic

I am bias as I am one of the original creators. Don't let that put you off, as these days only about 2% of this is mine, if that. It is almost completely run by the other guy now, who I am sure would appreciate anyone poppin over there to give it a bit of a look.

Tell him HeDanny sent you. :)

Romantically Apocalyptic/ - Destroyed world, over the top humor and beautiful art.

A few more webcomics I've read in the past, or read irregularly:
-DM of the Rings
-Darths & Droids
-VG Cats and spinoffs

Darths & Droids tries really hard to emulate the style of DM of the Rings, but the tabletop gaming advice is really esoteric at times. I'm guessing they're trying to cover fresh topics, but DM of the Rings already went over all the major ones. I read it for the story.

I've read quite some webcomics but the only ones I still visit regularly are "Goblins" and "Order of the Stick". The others either didn't keep my interest or stopped getting updated.

Sorry I'm necroing this thread (if someone is bothered by it), but I'd like to share this KickStarter success, and considering it's about Order of the Stick, I thought this could be a fine place for this. Wow... You can certainly say it was a popular initiative.



(If you don't want to/can't follow the link: it's a KickStarter project raising funds for the reprints of some OOTS books, and instead of the projected $57,750, it collected $1,254,120.)

Our Valued Customers

Things overheard in a comic book store.

Well you know what. This is a bump and not a new thread at all.



So, apart from the OVC mentionned right above, I regularly check :

Dr McNinja : Cheerfully over-the-top adventures of a mix of way to many action tropes. Often clumsy, always likeable.

Penny Arcade : Gaming-related comment strips, sometimes obscure to me (you really have to have played the given fashionnable console game they had in mind, in order to get it). The lengthy accompanying texts -on a separate page- are always an excellent read too.

XKCD : Nerdy jokes, sometimes excellent, sometimes just pompous or cheap. When it's good it's real good.

Oglaf : Light, fun and often (not always) sexual. There's a likeable tone and style to it.

False Positive : Little twilight-zone-like horror stories, very atmospheric. Most of times, the realist drawings are excellent, though it gets occasionally destroyed by odd perspective blunders. The latest, ongoing, story shows an unwelcome change of graphic style.

Hark a Vagrant : A hyper-talented historian's highly cleverly ironic takes on various historical tidbits or fictional figures. I love sketch-based drawings, and those impress. Eventually bought her book, actually.

Dead Philosophers In Heaven : Imaginary (and rather parodic) dialogues between classic figures of ancient and modern philosophy. Alas, very seldom updated.

Nedroid : Random randomness by an author who just doesn't care (and alas doesn't often care updating either). I especially like how the most obnoxious character resembles (accidentally) an obnoxious swiss marketing maskot that was irritating me since childhood.



I used to follow :

Axe Cop : Random action-movies-like stories, written by a little kid and drawn by his bigger brother. Used to be absolutely hilarious, alas, the litle kid grew up, and the self-awareness starts to show.

Whomp : Sometimes fun self-derogatory strips about an overweight overgeeky author, but occasionally too close to his personal neurosis to be completely enjoyable. Some issues seem too sincere to be genuine jokes, and that makes me ill at ease.

Bad Machinery / Scary Go Round : Excellent "kid sleuthing" stories where kids feel like kids. Lost interest after a long while, for no other reason of growing tired of this universe and stories. It's objectively good work though.

Alpha Flag : Used to be a very intriguing, mysteriously surreal story, but looks like it was abandonned mid-way, so, gave up on its hypothetical continuation...

Sailor Twain : Absolutely excellent tale about old west mermaids. Delightfully haunting, once you get used to the amateurish but efficient style. The story is complete now, so, no new pages to follow. But it's worth the occasional re-read.

Delilah Dirk : Gorgeous, frantic and witty cloak-and-dagger adventures in 1800s East Europa. Again, it's a full complete story (or wait, is it still?), and the protagonists only return in a buyable book. But the available story is with the ride.

The Trenches : A series of strips about gaming industry debugging work, accompanying unrelated testimonies and anecdotes on the working conditions. Used to be cool. After a few authors changes, became utter crap.



I happily stumble upon :

Wonderella : A simetimes fun parody of superhero stuff.

Saturday Morning Breakfast Cereals : Borderline XKCD-like humour, sometimes trying too hard.

Toothpaste for dinner : Surreal doodles, occasionally funny, but meh on the long term.

Perry Bible Fellowship : Excellent dark cynical disturbing humour, but too seldom updated.



I can't stand :

Questionable Content : It's lame.

Least I can Do : It stinks.

C-A-D : Urgh, just go away.

Some threads simply should be considered immortal because their contents are valid for years to come. Although some webcomics do disappear, (and even good ones aren't immune, ) if they are good they have a better chance of sticking around. And this is why I'm also bumping this thread.

Webcomics I follow regularly:

xkcd - no presentation needed;
Order of the Stick - ditto;
Dilbert - ditto².
Grrl Power - I'm surprised it hasn't been mentioned before cuz it's widely known;
Kiwi Blitz - cartoony-looking, and it is kinda light-hearted most of the time. But not all the time;
Darths & Droids - my own forum avatar is cut from one of their strips;

and I recently discovered and fell in love with <span class="bold">Shotgun Shuffle</span>. Can't recommend it enough. Check an example of a self-contained joke (as opposed to those that need a bit of context), or [url=http://shotgunshuffle.com/comic/heads-or-tails/]this one for another great opportunity to ROFL.

Edit: Had forgotten Dilbert