The 50 dollar copy now has a digital copy with it so you can keep your box sealed if you want.
Shit, I may have lied, now I can't find the reference.
EDIT: Hell yeah, wasn't lying:
"I am a collector, can I get a digital copy with my Large Box Copy so I don't have to open the box?
Due to popular demand, the $50 pledge for the Large Box Copy now also comes with a Digial Download copy of the game. We understand the collector mindset!
Last updated: Tuesday Mar 13, 12:54pm EDT"