You're choosing a target. Just like in all the other RPGs using dice rolls. And as for missing ... Just use your bloody imagination. ... ... Just like in all the other RPGs using dice rolls :D
It sure as hell doesn't feel like "targeting" if I have to get the timing right, avoid hits and aim precisely and the perspective doesn't leave much to the imagination. As I said, for me the perspective changes everything as does the fact that everything controls like in an action game and you have to act during combat like in an action game - only that you're being hindered by some abstract rules in this not at all abstract game. It's something completely different for me in an isometric and especially turn based game.
and NO, I've never done that :)
That's sad. You, and all other women out there, should do it more often. If it hadn't been for an accidental ball kick by his female co-worker my buddy wouldn't have found out that he had testicular cancer, at least not so early.