I can see myself getting through ME3 a couple of times, maybe three. The larger supporting cast in ME2 allowed me to run through it many times just to hear their reactions to the events. Its not really as attractive an option in ME3. Team members are tied to their particular mission, appearing as/when the game dictates.
True. However, the bigger replay factor for ME3 would be the conclusion and their effects anyway, as all comes together now. For example how the game reacts if you didn't touched the arrival DLC at all, took Morinth instead of Samara, Tali died on Suicide mission and so on.
While the game didn't impressed me at first, it delivered a lot up to now. Tuchanka was a turning point to the better for me, bringing back those great moments and I'm not talking about the "epic" ones - even with the solution for the Reaper being way too obvious. As well as the Samara plot line, Thane or the Quarian / Geth dispute (where I'm at right now).
However, it also had it's weak points, like talking to Jacob on the Citadel or Mirandas plot line (so far).
Overall it's great as far as I can tell, but they slipped a few times too often and didn't quiet nailed it to the point as before.