I don't think I even played it with anything other than the keyboard. It auto aims at important points anyway.
The reason I asked is because a year ago, when I last used VirtualPC, I noticed a problem with some games - specifically the tendency to freeze completely in the simulation. Only three games out of maybe twenty did that, as I was testing VPC at the time. It's just a gut feeling that The Infernal Machine might fit the criteria for that. Or maybe it was just a problem on my end the whole time. Anyway, just curious.

You could do that but why make a Virtual setting for one or two games? Plus this allows you to play it on your actual OS. :)

Old thread I know, but for what it's worth I found that after getting the new installer as already explained, and after having issues myself, I installed into the regular Program Files and not Program Files x86. Didn't have to tweak a thing, worked right off the bat.