Gothic 1 & (less so) 2
They don't end up really "destroyed", they still are fine game, but the clumsy keyboard-only control scheme, and the unintuitive inventory UI almost ruined G1, IMHO... what's worse is that it wasn't even really justified from a design point of view, just a developing time shortcut; the game was recent enough to have seen previous examples of mouse&user friendly RPG UI done well, and even a basic Diablo-like interface would have been enough
I never really understand why people complain about this -- I'm playing through them now and the controls are fine. Movement is through typical WASD. Interacting with objects involves left mouse button. Melee combat involves holding the button and swinging in different directions. Ranged and spell combat is easier/standard ARPG stuff. Inventory is just a matter of moving through the lists either up/down or left/right and mouse/up to equip or mouse/down to drop. I mean, yes, it takes maybe ten minutes to tinker around with it but after that it is fairly intuitive.
I can't recall what they picked for "pick up" as a command, but it was non-obvious, something like right-shift+enter or some such.
In G1 it is action/left mouse and movement up. G2 dispensed with the need to use movement in conjunction with the action/mouse so it is even easier. I'm really not seeing the awkwardness. Note that you have to choose the alternate control scheme and rebind the keys but... I assume checking out the keybindings is standard practice for most gamers these days. Well, PC gamers. I know I do it before I start any game.