In this corner, we have:
The Vault Dweller of Fallout fame.
A young fellow who left his home in Vault 13 to seek out a water chip, he quickly became one of the most influential figures in the Wastes. Facing down mutants, raiders, and all manner of other horrors leading up to the enigmatic Master himself, the Vault Dweller has come through the worst of circumstances still wearing that goofy '50's grin.
The Vault Dweller could be many things, from a smooth-talking sniper to a pacifistic scientist to a retarded superhuman smashing machine. "He" could even be female. He could be armed with guns, knives, explosives, or his fists, and armored in a super-suit or whatever junk he could find. But, whatever path he takes, there is no doubt that an experienced Vault Dweller can be the absolute best in the world at any one thing, or even any two things... but could the Vault Dweller be crippled by overspecialization?
And in the other corner, we have:
Marked One, AKA S.T.A.L.K.E.R, who won glory in the Shadow of Cherrnobyl.
Marked One is a mysterious figure in many ways. No one knows exactly where he came from or what he's doing, but one thing is for sure; he'll find a way to survive, against any odds. Whether he faces bandits or mutants or hazardous radiation or brain-scorching radiation or the entire freaking Ukrainian Army, he'll still manage to pull through.
Where the Vault Dweller is notable for exceptional talent in one or two things, the Marked One is skilled in many things. An acceptably good marksman with all manner of weapons, a decent paramedic, a passable thief, and a masterful wildnerness-survivor, the S.T.A.L.K.E.R. is equally good at scavenging, trespassing, adventuring, loner-ing, exploring, and robbing. He too could be armed with just about anything, but is somewhat distinct from the Vault Dweller in that he can buy gear from outside of the Zone instead of always having to scavenge or buy what other people scavenge; for this reason, the Marked One is usually better-armed than the Vault Dweller. But are arms alone enough to take out the dude who conquered a mutant horde?
Who will win? You decide!