I keep getting this error when trying to run the game. I've already changed my graphics mode setup to 'OpenGL' and done things like right clicking file>run as administrator & changing my display settings to 16bit as well as setting the compatibility mode to run in 640x480 but none of these work. Help?
Using Vista Premium 32bit for OS

Thanks, I thought GoG would've made it more clear to use. Total noob at DOS commands, eduke32 works brilliantly without the head-scratching method :P
Do all GoG games rely on DOSBox?

No, just the ones that were originally designed to run in DOS. Though some of the games have user-made windows ports like eduke32.
Newer GoG games that were designed to run on Windows generally run fine on both XP and Vista.

How do I get it to work in either dosbox or eduke32? I tried both and neither worked.