If you are using eDuke32 and having problems then all I can suggest is playing with the settings. Extract the eDuke32 archive (or run the installer if you have the installer version) then copy the DUKE3D.GRP file into the eDuke32 folder.
Run eDuke32 and select a resolution (start with a small resolution, maybe in a window if you want - the in-game settings allow a resolution change anyway).
As for the eDuke32 HUD, if you shrink the HUD slightly (I think only one notch down) then the original Duke Nukem 3D HUD should be shown. eDuke32 just has a minimal HUD as an option to make it like more modern shooters.
When you get eDuke32 started up, change the video settings. You can switch all the lighting effects and model effects, etc off to make it look exactly like the DOS version.