Hey fellas,
I'm up to the level one helicopter battle and if I die during the part where you're on the helicopter's ladder, the game crashes back to desktop.
I'm using windows vista home premium.
The crash is annoying as I have to start the entire level over, can't just resume the boss battle as auto-save is disabled during this boss battle.
Any suggestions?
ps - This is one awesome game. :-)

Unfortunately this is a well-known issue and I don't know of any 100% fix for it. I have the same bug as well.
See this thread for various suggestions.
http://www.gog.com/en/forum/duke_nukem_series/prism3d_error