I downloaded Duke Nukem 3D Atomic Edition from GOG (my first game from GOG) and strongly disliked the default control setup. Where was Mouse Look!? Argh! Long story short, I downloaded EDuke32 to address this problem and update the graphics.
Here's the problem I faced: when I ran Eduke32.exe the text on the menus was unreadable. I searched in vain for an answer to the problem, but finally got it working by fiddling around.
Here are the steps I took:
1) I deleted the file EDuke32.cfg to un-do any fiddling I'd done previously.
2) I started up EDuke32.exe. When it asked if I wanted to copy my DUKE3D.CFG file, I said no (so it would create a new config file).
3) At the configuration menu I set Video Mode to my monitor's preferred resolution, which in my case is 1440 x 900. Yours may be different. I also selected Full Screen, but not Polymer (though I may try that later).
4) I clicked the Start button then pressed Esc 3 times until I got to the episode selection menu (which was impossible to read). I selected the first episode, then on the next illegible menu I selected the first difficulty level so I wouldn't have to worry about getting shot immediately!
5) Once the game started, I pressed Esc to bring up the Options menu, which was (you guessed it) also unreadable. I selected the 4th item from the top, which is Options.
6) At the Options menu I selected the Video Setup menu, which is the 3rd item from the top.
7) If you've done everything I've said (and I've described it accurately) you should now be at the Video Setup menu. Move down to the item that is second from the BOTTOM of the menu. This is "Texture Filter". Press your Left Arrow button several times; there are four or five alternatives, as I recall. You may see a marked improvement! In my case I found that the "Nearest" setting was crisp, though pixelated, while the "Linear" setting was more pleasant to look at. The main thing is, though, I could now read the darn text.
8) Now that everything was working well, I selected "Apply Changes" and then Esc'd my way back to the episode selection menu.
I hope this little guide helps people out!
P.S. It probably doesn't matter, but I'll mention that I'm running Windows XP SP3 on a Hewlett Packard Pavillion A1410Y. My monitor is a ViewSonic VA1703wb. Maybe one day I'll describe the trouble I had getting that thing to work right with my computer.