hudfreegamer: I tried using the xbox 360 controller with Eduke32, but it was horrible. The controller seemed to be recognized, but the stick settings were all wrong and I couldn't figure out how to make them work correctly. That, and the menu cursor would keep moving. I tried adjusting the dead zone, but nothing I changed them to had any effect. So, in game Duke kept spinning and strafing.

I can't find any information that says if the controller would work with dukeplus.

I'd expect you'll need to use xpadder to actually play with a controller.

There is an updated version on Steam called the:
Duke Nukem 3D: Megaton Edition

That supposedly has controller support. Obviously, that doesn't help us.