Duke Nukem 3D is a milestone in FPS games. The gameplay was quite funny, scenarios detailed and weapons very strange & various. But the Duke himself is the funniest figure in an action game ever. Quotes from Nuke's mouth are still the best.
So "Guess again, freakshow. I'm coming back to town, and the last thing that's gonna go through your mind before you die... is my size- 13 boot!"