I'm running a NVIDIA GeForce 8600M GT at 1680x1050. Windows Vista 32-bit. 2GB RAM.
When I run the game, I get all kinds of visual glitches. The screen flickers, eyes pop out of their socket, textures tear off their frames, etc. I have read that turning down water detail and shadows, turning off antialiasing, and turning off the HW Vertex processing fixes these problems.
While it does fix all of these problems, the game takes a huge hit to its framerate without the HW Vertex processing enabled.
Solutions? Thoughts?

Old topic for old game with old problems. Above recommendations to enable all Manual Compatibility settings (leaving W buffer OFF) addressed all flicker/artifacting for me. Water Detail, Antialiasing, Flare, and Shadows quality are all set to the highest, and confirmed all graphics features are working in-game, including water.

No need for messing with driver control panel overrides.

System:
AMD FX-8320
Radeon HD7850

I personally found the recommendations here very helpful here. I was getting a lot of screen flickering on my Win 7 with AMD Athlon quad processor machine when I first acquired the game. I went the manual compatibility route and turned off HW vertex which seemed to solve it.

I also wanted to note that I saw the game was updated recently by GOG galaxy client. Experimentally, I set the game back to the automatic settings through the BG&E settings and now the screen flickering is no longer present at least not for me.

Thank you all for the helpful tips.

Nvidia GeForce 6150SE nForce 430

Disabling HW Vertex Processing in Settings worked for me!

I also followed other instructions in Nvidia Control Panel under 'Manage 3D Setting', including:

Under Global Settings:
Setting Anti-aliasing to 2x
Setting 'Texture Filtering - Ansiotropic filter optimization' to Off
Setting 'Texture Filtering - Negative LOD bias' to Clamp

After changing settings in Nvidia Control Panel, I still encountered graphical glitches and various screen/object tearing.
Disabling HW Vertex Processing is what seems to have done the trick for me.

I'm surprised my old clunker of a potato PC can run this game at full resolution! :)
(1377x768 for those that are wondering)

EDIT: I have confirmed that disabling HW Vertex Processing was what did the trick. I changed all my Nvidia settings back to default and didn't encounter any graphical errors.

Though as someone else mentioned, the game does take a small hit to performance. Not bad so far though on my machine. I'll add I'm running a single core 2.3ghz LOL

Configuration of my laptop is:
Windows Vista Home Edition
Intel Core 2 Duo 3 Ггц
RAM 3 Gb
nVidia GeForce 9500m 512 Mb

After first start of the game i experienced all the same glitches whic are discussed in net.

Here's the way i finally could desided this problem:
1.Settings in nVidia Inspector:
"Antialiasing - Mode" - "Override any application setting
"Antialiasing - Setting" - it's recommended set something instead "Application-controlled/off", i set "2x"
"Texture filtering - Anisotropic filter optimization" - set on "Off"
"Texture filtering = Negative LOD bias" - "Clamp"

2. In "Advanced Settings.exe" I set options as follow:
- "Water details" - "Low" (for normal FPS into the city"
- "Antialiasing" - "Off"
- "Shadows quality" - "Low"
- The next boxes are unchecked- "SSE", "HW Vertex Processing", "W Buffer"

3. Start the game only by GOG Launcher ("Launch Beyond Good and Evil"). If i use "BGE.exe" instead, all glitches appear again.

Voila finally!) Some minor glitches on textures are appearing sometimes, but game now is playable.
P.S. There are pics with view of settings in attachments.

Asus R9 280 here. The game has graphical flickers I'd like to get rid of. The radeon settings only see my steam games, and the game (BGE) does not start in a launcher. Any advice how to get to wherever the option to disable vertex processing is?

Your settings worked perfectly with my 970, no more glitches ! Thanks !

I only needed the Maximum pre-rendered frames = 1 combined with turning the HW Vertex Processing on in the game launch settings. Anyway, thanks for pointing me in the right direction to fix the mess I was in!

Same, setting Maximum Pre-Rendered Frames to 1 stopped all texture flickering issues for me with HW Vertex Processing enabled, even with antialiasing also enabled.

This finally made the game playable for me. Over the past two weeks, I tried a lot of different things but simply enabling everything except "W buffer" gave me great FPS with zero graphical glitches (two of my main issues).

Thank you very much.

Works great on my 1080GTX Thank you

I tried every suggestion in this thread without any luck. But as soon as I changed the compatibility mode on BGE.exe to Windows XP Service Pack 3, all the problems were solved. I'm running on an AMD Ryzen 5 1600 with AMD Radeon HD 5770.

Alternatively, Idarion's patch enables widescreen and eliminated the visual glitches on my machine.

I also struggled to get this game running properly on my system (AMD Ryzen 5 1600, NVIDIA GeForce GTX 1070). I ended up with these settings, which worked great throughout the whole game:

- Apply Widescreen fix by nemesis 2000 to make full use of my native resolution (see PCGamingWiki for instructions)
- Use DxWnd to run it in borderless window (see PCGamingWiki for instructions)
- Reduce the refresh rate of my gaming monitor to 60 hz in NVIDIA Control Panel
- Set my native resolution, 60 hz and all quality options, including anti alias, to max in SettingsApplication. Manual compatibility settings are turned off, everything greyed out there is on default (all ticked but W buffer).

Flickering is gone, cutscenes run at normal speed and no letterboxing. The only thing that doesn't work is alt-tabbing, but I can ctrl+alt+del and quickly click something on another screen to get the game out of focus.

Okay, since I've been trying so hard to finally make this game working again for like... 5 or 6 hours, I assume I need to introduce you to the results of my attempts.

I read through numerous posts both here on GOG and Steam, fiddled with settings and tried installing mods like Widescreen Fix or ENB. These are good mods hands down, but sadly none of them solved my issues completely. These included all you guys had mentioned here: texture flickering, audio desync and, the most serious of them all, bizarre game speed and FPS shenanigans, when the game ran either too fast or too slow.

It seems I finally managed to figure out the correct settings for all of these to go away.

First step: no mods installed, only settings.
Second step: 60 Hz refresh rate.
Third step: please see a screenshot of my Advanced Settings tab attached below.

It fixed the problem. No mods and no visual or FPS glitches of any sort.
My system specs are: Windows 10 64x, AMD Ryzen 5, GTX 2070.

Hope it helps!