Which means no reload if death screen appears.

I've did it once and it is really fun. Playing as a technologist, the key is to have as many restore life items bought from herbalists, preferably one in each companion's inventory so that they can resurrect you immediately if you get killed.

I'm on a new play and it was a very close call, my entire party was slaughtered in the basement with the Lord of the Damned in Ashbury (Virgil, Sogg and Dog). We had two restore life items which I used on Virgil and Sogg, and for the Dog I had to buy a resurrection scroll from the magic vendor (over 5000 gold!) since the herbalist had no restore life in stock.