I love Arcanum in general, but was reminded today why it sometimes would irritate me:
Getting ganked on the world map by level 20 Bears/etc when your party is low level :(. If you haven't saved in a bit then lots of progress can be lost (thus why I save pre-travel and after each world map encounter [I name them pretravel and intravel respectively].
Happened to me 3 times in a row, had to keep reloading due to death. First time was level 20 Bears, then Level 12 Bears, then Level 14 Kite Scouts. I managed to kill off an encounter of level 12 Plague Rodents at least (it got close to death at one point for Virgil as he was hit 5 times in a row with +15 mag poison).
This was just on my travel to Dernholm, if I didn't have my 'old school' save mentality I would probably become extremely frustrated.

Yeah, true - it has gotten me out of the save often habit though (until forcefully reminded :p). The first encounter w/ the bears today lost me a few minutes progress (about half the distance to Dernholm from Shrouded Hills).
Older games death meant load a save or start over, now so many games have 'respawn' mechanics that it takes some challenge out I guess.

I agree with the frequent death. I've been experimenting a bit, and it seems like you really have to level up melee if you want to live through most of the "real" wolf attacks in the game. I'm trying to plan long term here and put a lot of points into intelligence/gun making so the end of the game will go smoothly. We'll see how that technique goes.

Dodge is pretty important to have, and since Melee and Dodge are big - Dexterity is a must raise stat (it is the one stat linked to a ton of skills).

It even says it in the game's tooltips :P

I find party members dropping their weapon underwater a pain (the sewer). I can't find it unless they run over it randomly.
Or, the fact that I can't access everyone's inventory in 1 screen like a Bioware D&D game.

Very much so. Real PITA when selling stuff since you have to trade items with your follower, then barter, then trade again. Repeat for the other characters. Same thing when repairing their stuff.
It's also annoying when you drop something and a follower picks it up. I had a fine sword get trashed and nobody would repair or buy it so I just chucked it. Virgil the Dope kept picking it up. Virgil, you doofus, it's useless! Leave the damn thing alone! Eventually had to put it in a crate, but I had to carry the thing around until I figured out how to keep his grubby paws off of it.
Oh, and you can't tell them to use a certain weapon over another weapon without taking the other weapon from the NPC and temporarily burdening yourself with the weight.

The good thing is that you can go over your weight limit without much consequence by a fair margin. Lightly Burdened status only gives a -1 to speed, and ups your limit to around 1200+ stones (well, it does on a char w/ 600 stones standard at least, so it may be around 2x normal max burden).
To drop items on the ground and keep NPC's from picking it up, just throw it down with another useless item (or at least an item you don't need). This will create a 'junk pile' that NPC's will not pick through.

The picking up items thing is really annoying. Once, Gar decided to pick up a 4000 stone boulder in Ashbury. Also, you or a teammate drops makes a critical miss and drops his weapon, and someone else picks it up, you have to comb through your 6 followers to find it...
Traveling around the map early game, especially as a gunner with limited bullets and money, is a huge pain.
And Black Mountain Mines of course.

I'm pissed that when I pay for two whores in Madam Lil's I can't choose one plus Belle the sheep. How dare they deny me my right to a threesome with a half-orc and a sheep?

Where do I start?
1. Fire elementals. Attacking them damages your weapons. Getting hit damages your armor. The XP they give isn't great and they can kill you if you're not prepared. This is especially trying when you're going through a whole cave of big ones when you're hunting for a certain magic weapon.
2. Rock elementals. Not as bad as fire, but much more common and therefore annoying.
3. Technology/magic imbalance. The vast majority of the powerful enemies you fight in the game are magic-based, so a guy specializing in guns or other techno-wizardry is at a disadvantage. This makes sense, story wise, but it's still annoying.
4. Guns aren't worth it. Besides the problem in #3, the best guns still don't do as much damage as you can do with a sword and a good strength score. AND you need to have a constant supply of ammo.
5. Grenades are broken. 1 AP to throw, good damage, and apparently no friendly fire damage. Enough molotov cocktails and a high dex score can take on the world.
6. Nobody makes ogre-sized armor, except for a few leather suits that you can only get off another ogre's corpse.
7. NPC AI is garbage, especially for spellcasters. Don't give your guys any expensive healing items.
8. Most of the NPCs have little or no personality after they join the party.
9. Without good combat skills, the game is virtually unwinnable. Without good diplomatic skills, much of the game's content is inaccessible. Good luck, antisocial thief types...
10. Random encounters with crazy things, as mentioned above.
11. Level cap of 50. Why? By 50, you're already probably strong enough to solo the final boss and everything else, so why prevent further development?
12. Black mountain mines, partly because they're so long, partly because they're linear, and partly because their longevity and linearity makes shipping loot out of there arbitrarily hard.

The ending bothers me quite a bit. Not story-wise - I liked the story a lot. There just isn't a transition to the cgi scenes, and it all feels unfinished/unpolished stylistically.

I'm just getting started. maybe some things I am seeing were suppose to be fixed?

Gar can't wear most armor. Did they fix this? I swear I did the unofficial patch, but with some many stupid things still going on it seems like maybe I screwed up the patch or something.

stuff breaking. seems impossible to fix yea?

Does the virgil guy coutn against followers or not? Seems like you need an awful lot of Charisma to up your follower number . People were talking about building an army...but to do that you got to put like 10 levels into just Charisma right?

If 50 is the level cap, then that is like 1/5 of all levels.

UI seems pretty tedius.

Crit-fails on a backstab...I was taking 90 points of damage when I only had something like 40 max HP, killing myself from a single miss! It still happens once in a while & it just doesn't seem right. I mean, what's happening? Am I starting a roundhouse swing with my dagger & coming full circle to punch myself in the kidney??