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I had the problem with flickering and mouse trails. Running two AMD 7770 cards in Crossfire mode. Disabled crossfire for Arcanum and the problem disappeared. Running perfectly now.
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Adamas57: I had the problem with flickering and mouse trails. Running two AMD 7770 cards in Crossfire mode. Disabled crossfire for Arcanum and the problem disappeared. Running perfectly now.
Try renaming ddraw.dll in the root directory...it's an old version of the file and renaming it allows the game to use the up to date version of ddraw.dll in your system directory. Made a huge improvement for me.