For one part: I know the game is glitchy as hell. And most people who play it, like me, save after every minuscule discovery. But, if you want to complete the game, you will read this.
Do not get caught by the sentry, or guard bot, or droid in the first cell block in the Alcatraz level! It will crash your game!
Or it might not.
It crashed my game at least 2 dozen times before I realized... hey, if I walk up to this thing... will the game crash? And the answer was yes. I thought it was just the game being funky, as always -- but it wasn't.
Every time I got caught by the thing, a Windows Error Message popped up, telling me there was a problem with one of the downloaded AVI files.
No freeze ups, nothing. It completely shuts down the game.
I know this might, or probably is old news to most. But, just wanted to warn you guys.

You may want to contact gog support about that, if the crash is consistant and the error complains of a messed up movie file it might be something they could fix.