Hi !
I get this error every time I start a game, or even when I click on the credit button.
I suppose this is due to an issue with the graphical engine of the game, but running it in compatibility mode doesn't help at all.
I got an ATI hd5870, and I7 860 proc and I run windows 7 64 bits, if that's any help.
I tried to tweak the options in the advanced options menu at start, but no dice.
EDIT: Apparently I can run the game in 1440*900, but not in 1680*1050.
I can start loading levels in 1440*900 and then switch to 1680*1050, and it does work, but then I have the same crash at the next loading

Hey guys. I'm running blood2 on Vista64 with compatibility mode set to win98 and running as admin. This works fine as I managed to complete the game.

The expansion however has some issues. It crashes with the usual MFC error when I switch from the Jojo level to the haunted mansion one. I hooked up a debugger and noticed that it crashed in the imusic dll, so I disabled music and managed to load the level without issues.

Thought this might be helpful to some people.

Thanks for the tip on how to get this game to run :) Just changing the compatibility mode to Windows 98 / Window ME but leaving the rest of the settings alone as they were setup when installed worked out great on my Windows 7 X64 setup.